The Dallas Cowboys won in Indianapolis. They paid for it.

Starting tight end Jake Ferguson and No. 2 running back Tyler Goodson will both miss "multiple weeks" coach Brian Schottenheimer said Monday.

Ferguson sprained the posterior cruciate and medial collateral ligaments in his left knee in the third quarter of Sunday's 27-23 win over the Colts, according to reports. He was hit awkwardly at the end of an 11-yard catch and grabbed his knee right away. He got it taped on the sideline but did not return. Ferguson is second on the team with four touchdown catches.

Goodson played through it

Goodson hurt his knee in the second quarter but came back in the second half and finished with a career-high 77 yards on 12 carries. Scans on Monday showed more than he let on.

Schottenheimer said Goodson "has been incredible for us really the last two weeks" and that players like him "want to tough it out. They care. They want to win."

There is a roster squeeze too. Dallas has only one designated-to-return slot left on injured reserve after using the tag on seven players. A player placed on IR misses at least four games.

Who steps in

Tight end Luke Schoonmaker has missed two games with a groin injury but will be available this week. Behind starter Javonte Williams the only back on the 53-man roster is fullback Hunter Luepke, though Israel Abanikanda and Jashaun Corbin are on the practice squad.

"I have a lot of confidence in Izzy" Schottenheimer said. "But I'm not going to pretend that losing Goody doesn't affect us. The guy's been playing great football."

Receiver George Pickens, cornerback Joey Porter Jr. and linebacker DeMarvion Overshown will be limited in practice before a call is made for Sunday's game against the San Francisco 49ers. Safety P.J. Locke has been ruled out after his second concussion in two weeks.