The Colorado Avalanche lost much more than a hockey game Thursday night. Superstars Nathan MacKinnon and Cale Makar both left with lower-body injuries in the second period of a 4-3 overtime loss to the Ottawa Senators.

The team ruled both players out for the rest of the night. Coach Jared Bednar had no update after the game.

Two stars down within moments

Makar got hurt first. He took a shift that lasted only four seconds before heading to the locker room. He came back for one brief 23-second shift but stayed on the bench after that and did not return for the third period.

MacKinnon went down moments later. He took a check in the hip area from Senators defenseman Artem Zub and grabbed his right side. He sat on the bench for a few minutes before heading down the tunnel with just over eight minutes left in the period.

MacKinnon leads Colorado and is fifth in the NHL with 30 points. Makar has 23 points, third among all NHL defensemen. He had also left practice early on Sunday as a precaution.

Pinto's birthday winner

The shorthanded Avalanche still fought back. Parker Kelly tied it 2-2 with a shorthanded goal early in the third period. Gabriel Landeskog then gave Colorado its first lead on a power-play snap shot.

Drake Batherson tied it with 3:56 left in regulation when he buried a loose puck in the crease. Shane Pinto won it 2:08 into overtime. He picked off a pass in the Colorado zone and fired a wrist shot in on his 26th birthday. It was his second goal of the night.

Linus Ullmark made 26 saves in his first game back since Oct. 21. Scott Wedgewood stopped 22 shots for Colorado.

What comes next

Colorado fell to 11-6-3 and plays at Montreal on Saturday. Ottawa improved to 12-6-2.